Three friends, Tom, Jerry and Dan (Dax Shepard, Matthew Lillard, and Seth Green) have planned since they were children to seek a fortune lost by a famed hijacker, DB Cooper. They had gotten the idea from their childhood friend Billy who has since died. They set out on a canoing trip with a map that points out where the fortune should be located. As they head down the river, they encounter a bear, two armed drug dealers that had a marijuana crop that they stumble upon, and two bizarre rain forest girls. The bear and drug dealers proceed to hunt them down for the rest of the movie in a thrilling yet hysterical chase.