Semi-washed up FBI, Jonathan Ecks (Antonio Banderas) must team up with his archenemy of many years, DIA agent Sever (Lucy Liu). Agent Ecks comes complete with a troubled past and a desperate need of a shave and shower. Agent Sever is a slick, silent and deadly professional, whose history is as vague and mysterious as she is. Through a series of action-packed twists and turns, the two agents play cat and mouse with one another until they realize they must put their differences aside, as best they can, and join forces in order to take down a far “greater evil”, even if it means killing each other in the process.