Vincent Chase is a young, hot, up-and-coming actor living in Hollywood. Tonight, he must attend the opening of his latest movie "Head On". At the post-premiere party, Vince's agent, Ari, hassles Eric about getting Vince to read the script for a possible new project. Over breakfast, Vince says he's not going to do "Matterhorn" on Eric's advice. The foursome goes to meet with the director where Vince impresses him so much that Ari calls later to tell him that they've offered $4 million for the part. While Turtle & Drama celebrate, Vince lets him know that Eric is not too enthused about the script. Later, Ari & Eric share a rather confrontational dinner while discussing the future of their star's career.

Ignoring the negative review from Variety, Vince ramps up his already excessive spending by leasing a new Rolls Royce. Ari urges Vince to get a "real" manager, causing a wounded Eric to do some soul searching.

Partying after a boxing match, Vince runs into Jimmy Kimmel, who immediately does his best to get Vince to commit to an appearance on his show the following night. Also at the party, Luke Wilson tells Turtle and Drama about his new home theater setup, planting the idea in their heads that they need an upgrade.

Vince's major work for the day is a stop at Big Boy's Neighborhood, a local radio show. As a result of the appearance, Vince secures a date for himself with Justine Chapin. While everybody gets ready for the night's activities, Ari video conferences with Eric to tell him that matinée numbers for Vince's movie have been "less than stellar" because it is in direct competition with the latest Pixar feature.

The boys are less than pleased that Vince's latest fling, Fiona, has over-stayed the 3-day rule that Vince instated long ago. Eric is re-introduced to an old acquaintance who may have just the script that Vince has been looking for: a story about a guy from Queens. Turtle tries to find a way around a weed drought in L.A.

Drama prepares to meet his potential new agent and drags Turtle with him while Eric & Vince attend a special meeting. Later, the boys attend Gary Busey's art opening where they bump into aspiring agent Josh Weinstein.

Eric is concerned over the choice of director, an indie loose cannon named Billy Walsh, for Vince's new film. Meanwhile, Drama lobbies for a supporting role, while Ari finds he can't mix business with pleasure.

As production on "Queens Boulevard" is about to begin, the boys are preparing to go to New York City for the next three months. Vince puts Turtle in charge of their "bon voyage" party, which proves to be a pain-in-the-neck for Eric later on. Meanwhile, Drama has a problem when an audition for a pilot conflicts with his small role in Vince's new movie. Meanwhile, Eric wants a title commensurate with his responsibilities, but when a dinner meeting ends on a sour note, it looks like Vince's entourage will be minus one.